Seth Gecko, sole survivor of the cult action film From Dusk 'till Dawn, has been sentenced to death in place of his brother, and has 72 hours left to live. With the help of the few remaining human survivors and armed with raw combat artillery, Seth might make it through the night. The game features 19 weapons, including M9 and paralyzing guns, a sander, a circular saw, and flash grenades. From Dusk 'till Dawn also includes destroyable backgrounds with "intelligent" effects, 20 challenging levels, and original new music mixed with the soundtrack of the movie.

You are famed vampire slayer Seth Gecko, sole survivor of From Dusk Till Dawn. You've been convicted and sentenced to death for a crime you didn't commit. You await your ultimate fate out at sea board the Rising Sun, a massive tanker which has been transformed into a maximum security prison.